New-generation Guide RNA (LgRNA) Platform
a laboratory
  • Efficacy: Dual guide RNAs < sgRNA < LgRNA
  • LgRNA is highly pure (up to 99% by LC/MS) and free of detectable truncated spacer sequences
  • High purity results in very high specificity
  • Chemical modifications of LgRNA limit immunogenicity
  • LgRNA conjugates enable nucleus uptake and cell-selective delivery

Non-immunogenic STAR Editor Platform
DNA editing
  • Precise editing by a DNA dependent polymerse
  • nCas9/templated DNA repair resulting in minimal DSBs
  • RNP conjugates for non-immunogenic targeted delivery
  • Ability to insert stop codon anywhere to ensure minimal truncated protein byproducts for anti-cancer and antiviral therapy
  • Ability to perform single base corrections, and insert/delete short or long DNAs
  • Capability of multiplexing and multiple-dosing