Star Editor for curing various diseases by precisely targeting disordered genes and genomes of pathogens
STAR Editor edits DNA precisely to disrupt and repair diseased genes.
- Seek a protospacer in the targeted genome by STAR Editor;
- Tag (cut and anneal) the gapped non-target strand with a ligated ssDNA;
- Amend (HDR) by host enzymes, which promotes the release of STAR Editor;
- Release of edited DNA.
STAR editor edits DNA precisely to accurately disrupt and repair diseased genes
LgRNA-enabled PRECISE Repair
- SegRNA has the DNA template for precise gene editing by a DNA polymerase
- SegRNA conjugates for nucleus uptake and selective cell-targeted delivery
- Full-spectrum editing capacity
- Multiple turnovers
- Transient multiple-dosing in vivo delivery methods: (1) LNP-based delivery of nucleic acids (mRNA + segRNA); (2) Non-immunogenic RNP conjugates